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Pharmacokinetic and Metabolism Studies Using Microdialysis Sampling

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      Besides, the average daily oral dose of mitragynine consumed is relatively low (approximate 0.3-5.1 mg/kg) as compared with the reported therapeutic dosage of about 3-100 mg/kg (i.p.) for antinociceptive activity in mice [11]. Microdialysis is a well-established sampling technique for in vivo quantification of exogenous and endogenous substances in both plasma and tissue [12]. It is commonly used for investigation of PK/PD relationship since concentration of the unbound drug is more correlated to the pharmacological effects.

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