Skip to main content
Log in

The Effects Of Hemodilution, pH, and Protamine on Lidocaine Plasma Protein Binding and Red Blood-Cell Uptake in Vitro

  • Note
  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

REFERENCES

  1. H. W. Beattie, G. Evans, E. S. Garnett, and C. E. Webber. Surgery 71:891–897 (1972).

    Google Scholar 

  2. F. O. Holley, K. V. Ponganis, and D. R. Stanski. Clin. Pharmacol. Ther. 35:617–626 (1984).

    Google Scholar 

  3. P. A. Routledge, A. Barchowsky, T. D. Bjornsson, B. B. Kitchell, and D. G. Shand. Clin. Pharmacol. Ther. 27:347–351 (1980).

    Google Scholar 

  4. P. J. McNamara, R. L. Slaughter, J. A. Pieper, M. G. Wyman, and D. Lalka. Anesth. Analg. 60:395–400 (1981).

    Google Scholar 

  5. G. T. Tucker, R. N. Boyes, P. O. Bridenbaugh, and D. C. Moore. Anesthesiology 33:287–303 (1970).

    Google Scholar 

  6. H. R. Ha, S. Vozeh, and F. Follath. Clin. Pharmacokin. 9(Suppl. 1):96 (1984).

    Google Scholar 

  7. P. J. McNamara, R. L. Slaughter, J. P. Visco, C. M. Elwood, J. H. Siegel, and D. Lalka. J. Pharm. Sci. 69:749–751 (1980).

    Google Scholar 

  8. P. A. Routledge, W. W. Stargel, B. B. Kitchell, A. Barchowsky, and D. G. Shand. Br. J. Clin. Pharmacol. 11:245–250 (1981).

    Google Scholar 

  9. K. M. Piafsky, O. Borga, I. Odar-Cederlof, C. Johansson, and F. Sjoquist. N. Engl. J. Med. 299:1435–1439 (1978).

    Google Scholar 

  10. F. Aronsen, G. Edelund, C. O. Kindmark, and C. B. Laurell. Scand. J. Clin. Lab. Invest. 29(Suppl. 124):127–136 (1972).

    Google Scholar 

  11. B. G. Johansson, C. O. Kindmark, E. Y. Trell, and F. A. Wolheim. Scand. J. Clin. Lab. Invest. 29(Suppl. 124):117–126 (1972).

    Google Scholar 

  12. K. M. Giacomini, S. E. Swezey, J. C. Giacomini, and T. F. Blaschke. Life Sci. 27:771–780 (1980).

    Google Scholar 

  13. J. E. Brown, B. B. Kitchell, T. D. Bjornsson, and D. G. Shand. Clin. Pharmacol. Ther. 30:636–643 (1981).

    Google Scholar 

  14. P. V. Desmond, R. K. Roberts, A. J. J. Wood, G. D. Dunn, G. R. Wilkinson, and S. Schenker. Br. J. Clin. Pharmacol. 9:171–175 (1980).

    Google Scholar 

  15. D. T. Mahin and R. T. Lofberg. In E. D. Bransome, Jr. (ed.), The Current Status of Liquid Scintillation Counting, Grune and Stratton, New York, 1970, pp. 212–221.

    Google Scholar 

  16. L. M. Dubé, A. Ho-Ngoc, R. F. Davies, D. S. Beanlands, N. Mousseau, and I. J. McGilveray. Res. Comm. Chem. Path. Pharmacol. 42:401–415 (1983).

    Google Scholar 

  17. L. M. Dubé, R. F. Davies, D. S. Beanlands, N. Mousseau, N. Beaudoin, B. Chan., A. Ho-Ngoc, and I. J. McGilveray. Biopharm. Drug. Disp. 10:55–68 (1989).

    Google Scholar 

  18. F. O. Holley, K. V. Ponganis, and D. R. Stanski. Clin. Pharmacokin. 7:234–251 (1982).

    Google Scholar 

  19. V. Sanchez, G. R. Arthur, and G. R. Stricharz. Anesth. Analg. 66:159–165 (1987).

    Google Scholar 

  20. K. V. Ponganis and D. R. Stanski. J. Pharm. Sci. 74:57–60 (1985).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Remmel, R.P., Copa, A.K. & Angaran, D.M. The Effects Of Hemodilution, pH, and Protamine on Lidocaine Plasma Protein Binding and Red Blood-Cell Uptake in Vitro . Pharm Res 8, 127–130 (1991). https://doi.org/10.1023/A:1015807129129

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1015807129129

Navigation