Skip to main content
SpringerLink
Log in

Sulfotransferase 1A1 (SULT1A1) Polymorphism, PAH-DNA Adduct Levels in Breast Tissue and Breast Cancer Risk in a Case-Control Study

  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

Gene–environment interactions are hypothesized to be major contributors to susceptibility to environmental carcinogens and interindividual variability in cancer risk. We present findings on associations between genetic susceptibility due to inherited polymorphisms of the Phase II detoxification enzyme sulfotransferase 1A1 (SULT1A1), breast cancer risk, and polycyclic aromatic hydrocarbon (PAH)-DNA adducts. A hospital based case-control study was conducted at the New York-Presbyterian Medical Center (NYPMC). The study utilized two control groups: one comprised of women with benign breast disease (BBD) and the other comprised of women visiting NYPMC for routine gynecologic checkups (healthy controls). Blood samples were collected from cases and controls; and breast tissue from pathology blocks was collected from cases (tumor and non-tumor tissue) and BBD controls (benign tissue). PAH-DNA adduct levels were measured by immunohistochemistry in breast tissue samples, and the SULT1A1 (Arg/His) polymorphism at codon 213 was determined by PCR RFLP analyses using DNA from white blood cells. Increasing number of His alleles was modestly associated with breast cancer case-control status, when cases were compared to healthy controls (p for trend = 0.08), when cases were compared to BBD controls (p for trend = 0.08) and when cases were compared to both control groups combined (p for trend = 0.07). Contrary to our hypothesis PAH-DNA adduct levels in breast tissue were not associated with SULT1A1 genotype. Our findings are consistent with a prior report that the Arg/His polymorphism in SULT1A1 is associated with breast cancer risk.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. ACS (American Cancer Society): Cancer Facts and Figures. American Cancer Society, 2002

  2. El-Bayoumy K: Environmental carcinogens that may be involved in human breast cancer etiology. Chem Res Toxicol 5: 570-585, 1992

    Google Scholar 

  3. Perera FP, Estabrook A, Hewer A, Channing KM, Rundle A, Mooney LA, Whyatt R, Phillips DH: Carcinogen-DNA adducts in human breast tissue. Cancer Epidemiol Biomarkers Prev 4: 233-238, 1995

    Google Scholar 

  4. Li D, Wang M, Dhingra K, Hittelman W: Aromatic DNA adducts in adjacent tissues of breast cancer patients: clues to breast cancer etiology. Cancer Res 56: 287-293, 1996

    Google Scholar 

  5. Rundle A, Tang D, Hibshoosh H, Estabrook A, Schnabel F, Cao W, Grumet S, Della Rocca A, Perera F: The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast cancer. Carcinogenesis 21: 1281-1289, 2000

    Google Scholar 

  6. Helzlsouer KJ, Selmin O, Huang HY, Strickland PT, Hoffman S, Alberg AJ, Watson M, Comstock GW, Bell D: Association between glutathione S-transferase M1, P1, and T1 genetic polymorphisms and development of breast cancer. J Natl Cancer Inst 90: 512-518, 1998

    Google Scholar 

  7. Rundle A, Tang D, Zhou J, Cho S, Perera F: The association between glutathione-S-transferase-M1 genotype and polycyclic aromatic hydrocarbon (PAH)-DNA adducts in breast tissue. Cancer Epidemiol Biomarkers Prev 9: 1079-1085, 2000

    Google Scholar 

  8. Zheng W, Xie D, Cerhan JR, Sellers TA, Wen W, Folsom AR: Sulfotransferase 1A1 polymorphism, endogenous estrogen exposure, well-done meat intake, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 10: 89-94, 2001

    Google Scholar 

  9. Weinshilboum RM, Otterness DM, Aksoy IA, Wood TC, Her C, Raftogianis RB: Sulfation and sulfotransferases 1: sulfotransferase molecular biology: cDNAs and genes. FASEB J 11: 3-14, 1997

    Google Scholar 

  10. Falany CN: Enzymology of human cytosolic sulfotransferases. FASEB J 11: 206-216, 1997

    Google Scholar 

  11. Glatt H: Bioactivation of mutagens via sulfation. FASEB J 11: 314-321, 1997

    Google Scholar 

  12. Williams JA, Stone EM, Fakis G, Johnson N, Cordell JA, Meinl W, Glatt H, Sim E, Phillips DH: N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast. Pharmacogenetics 11: 373-388, 2001

    Google Scholar 

  13. Raftogianis RB, Wood TC, Otterness DM, Van Loon JA, Weinshilboum RM: Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype. Biochem Biophys Res Commun 239: 298-304, 1997

    Google Scholar 

  14. Raftogianis RB, Wood TC, Weinshilboum RM: Human phenol sulfotransferases SULT1A2 and SULT1A1: genetic polymorphisms, allozyme properties, and human liver genotype-phenotype correlations. Biochem Pharmacol 58: 605-616, 1999

    Google Scholar 

  15. International Agency for Research on Cancer: Polynuclear aromatic compounds. Part 1. Chemical, environmental, and experimental data. IARCMonographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol 32, International Agency for Research on Cancer Lyon, France, 1983, pp. 1-453

    Google Scholar 

  16. US EPA: Aerometric Information Retrieval System (AIRS), Data for 1985-1990. Dr. R. Faoro. Environmental Protection Agency Research Triangle Park, NC, 1990.

    Google Scholar 

  17. Moore CJ, Tricomi WA, Gould MN: Interspecies comparison of polycyclic aromatic hydrocarbon metabolism in human and rat mammary epithelial cells. Cancer Res 46: 4946-4952, 1986

    Google Scholar 

  18. Calaf G, Russo J: Transformation of human breast epithelial cells by chemical carcinogens. Carcinogenesis 14: 483-492, 1993

    Google Scholar 

  19. Eldridge SR, Gould MN, Butterworth BE: Genotoxicity of environmental agents in human mammary epithelial cells. Cancer Res 52: 5617-5621, 1992

    Google Scholar 

  20. Mane S, Purnell D, Hsu IC: Genotoxic effects of five polycyclic aromatic hydrocarbons in human and rat mammary epithelial cells. Environ Mol Mutagen 15: 78-82, 1990

    Google Scholar 

  21. Miller JA: Sulfonation in chemical carcinogenesis-history and present status. Chem Biol Interact 92: 329-341, 1994

    Google Scholar 

  22. Surh YJ, Miller JA: Roles of electrophilic sulfuric acid ester metabolites in mutagenesis and carcinogenesis by some polynuclear aromatic hydrocarbons. Chem Biol Interact 92: 351-362, 1994

    Google Scholar 

  23. Miller EC, Miller JA: Mechanisms of chemical carcinogenesis. Cancer 47: 1055-1064, 1981

    Google Scholar 

  24. Rundle A, Tang D, Hibshoosh H, Schnabel F, Kelly A, Levine R, Zhou Z, Link B, Perera F: Molecular epidemiologic studies of polycyclic aromatic hydrocarbon-DNA adducts and breast cancer. Environ Mol Mutagen 39: 201-207, 2002

    Google Scholar 

  25. Zhang YJ, Weksler BB, Wang L, Schwartz J, Santella RM: Immunohistochemical detection of polycyclic aromatic hydrocarbon-DNA damage in human blood vessels of smokers and non-smokers. Atherosclerosis 140: 325-331, 1998

    Google Scholar 

  26. Flanders WD, DerSimonian R, Freedman DS: Interpretation of linear regression models that include transformations or interaction terms. Ann Epidemiol 2: 735-744, 1992

    Google Scholar 

  27. Glatt H: Sulfotransferases in the bioactivation of xenobiotics. Chem-Biol Interact 129: 141-170, 2000

    Google Scholar 

  28. Williams JA, Martin FL, Muir GH, Hewer A, Grover PL, Phillips DH.: Metabolic activation or carcinogens and expression of various cytochromes P450 in human prostate tissue. Carcinogenesis 21: 1683-1689, 2000

    Google Scholar 

  29. Falany JL, Falany CN: Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines. Cancer Res 56: 1551-1555, 1996

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Environmental Health Sciences, New York City, NY, USA

    Deliang Tang, Laverne Mooney & Stan Cho

  2. Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, New York City, NY, USA

    Andrew Rundle

  3. Department of Surgery, New York City, NY, USA

    Freya Schnabel

  4. Department of Surgery, Saint Luke's Hospital, New York City, NY, USA

    Alison Estabrook

  5. Department of Obstetrics and Gynecology, New York City, NY, USA

    Amalia Kelly & Richard Levine

  6. Department of Pathology, New York Presbyterian Medical Center, New York City, NY, USA

    Hannina Hibshoosh

  7. Department of Environmental Health Sciences, New York City, NY, USA

    Frederica Perera

Authors
  1. Deliang Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrew Rundle
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Laverne Mooney
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Stan Cho
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Freya Schnabel
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alison Estabrook
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Amalia Kelly
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Richard Levine
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hannina Hibshoosh
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Frederica Perera
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tang, D., Rundle, A., Mooney, L. et al. Sulfotransferase 1A1 (SULT1A1) Polymorphism, PAH-DNA Adduct Levels in Breast Tissue and Breast Cancer Risk in a Case-Control Study. Breast Cancer Res Treat 78, 217–222 (2003). https://doi.org/10.1023/A:1022968303118

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1022968303118

Search

Navigation