Abstract
THE many pathophysiological effects produced by endotoxins are subject to considerable variation. Such variation may serve as a useful tool for analysing the mechisms of endotoxin activity, if different strains of highly inbred animals raised in the same environmental conditions can be found to differ in their responses to the same materials. Previous observations have indicated that this might be so with regard to the intraperitoneal leucocyte response to endotoxin in mice1. The investigation reported here was initiated to determine the extent of the intraspecies variation in this type of cellular response and eventually the degree of genetic control involved.
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References
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SULTZER, B. Genetic Control of Leucocyte Responses to Endotoxin. Nature 219, 1253–1254 (1968). https://doi.org/10.1038/2191253a0
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DOI: https://doi.org/10.1038/2191253a0
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