Abstract
Cooperative and allosteric effects are explained by a theory involving not conformational changes but steric exclusion through interactions between multifunctional ligands which bind to common and topologically distinct subsites.
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FISHER, H., GATES, R. & CROSS, D. A Ligand Exclusion Theory of Allosteric Effects. Nature 228, 247–249 (1970). https://doi.org/10.1038/228247a0
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DOI: https://doi.org/10.1038/228247a0
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