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Novel 4-hydroxycoumarin anticoagulants active against resistant rats

Nature volume 253, pages 275–277 (1975)Cite this article

Abstract

FIELD populations of common rats (Rattus norvegicus) resistant to anticoagulant rodenticides (for example, Warfarin) have appeared1 in Scotland, Denmark, England and Wales, and more recently on the American continent. This resistance seems to be associated with a reduction in the efficiency of vitamin K metabolism1 and is an inheritable factor controlled by a single dominant autosomal gene. Various theories have1,2 been advanced to explain the underlying mechansim. Resistance to other anticoagulants has now appeared, that to coumatetralyl being the least effective1.

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Authors and Affiliations

  1. Sorex (London) Ltd., Research Laboratories, Lower Road, Widnes, Cheshire, WA8 8NS, UK

    M. R. HADLER & R. S. SHADBOLT

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  1. M. R. HADLER
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  2. R. S. SHADBOLT
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HADLER, M., SHADBOLT, R. Novel 4-hydroxycoumarin anticoagulants active against resistant rats. Nature 253, 275–277 (1975). https://doi.org/10.1038/253275a0

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