Abstract
The downstream (3′) long terminal repeat (LTR) of an avian retroviral provirus is unable to act as an efficient promoter of transcription when a transcriptionally active upstream (5′) LTR is present. This transcriptional interference may explain the observation that only deleted proviruses have been observed inserted adjacent to c-myc in avian leukosis virus induced lymphomas of chickens.
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Cullen, B., Lomedico, P. & Ju, G. Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesis. Nature 307, 241–245 (1984). https://doi.org/10.1038/307241a0
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DOI: https://doi.org/10.1038/307241a0
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