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Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesis

Abstract

The downstream (3′) long terminal repeat (LTR) of an avian retroviral provirus is unable to act as an efficient promoter of transcription when a transcriptionally active upstream (5′) LTR is present. This transcriptional interference may explain the observation that only deleted proviruses have been observed inserted adjacent to c-myc in avian leukosis virus induced lymphomas of chickens.

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References

  1. Hayward, W. S., Neel, B. G. & Astrin, S. M., Adv. viral Onc. 1, 207–233 (1982).

    CAS  Google Scholar 

  2. Hughes, S. H. et al. Cell 15, 1397–1410 (1978).

    Article  CAS  PubMed  Google Scholar 

  3. Sabran, J. L. et al. J. Virol. 29, 170–178 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Ju, G. & Skalka, A. M. Cell 22, 379–386 (1980).

    Article  CAS  PubMed  Google Scholar 

  5. Neel, B. G., Hayward, W. S., Robinson, H. L., Fang, J. & Astrin, S. M. Cell 23, 323–334 (1981).

    Article  CAS  PubMed  Google Scholar 

  6. Payne, G. S. et al. Cell 23, 311–322 (1981).

    Article  CAS  PubMed  Google Scholar 

  7. Fung, Y. T., Fadly, A. M., Crittenden, L. B. & Kung, H. J. Proc. natn. Acad. Sci. U.S.A. 78, 3418–3422 (1981).

    Article  ADS  CAS  Google Scholar 

  8. Varmus, H. E. & Swanstrom, R. in RNA Tumor Viruses 2nd edn, 369–512 (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  9. Yamamoto, T., Jay, G. & Pastan, I. Proc. natn. Acad. Sci. U.S.A. 77, 176–180 (1980).

    Article  ADS  CAS  Google Scholar 

  10. Hofer, E. & Darnell, J. E. Cell 23, 585–593 (1981).

    Article  CAS  PubMed  Google Scholar 

  11. Cullen, B. R., Kopchick, J. J. & Stacey, D. W. Nucleic Acids Res. 10, 6177–6190 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Cullen, B. R., Skalka, A. M. & Ju, G. Proc. natn. Acad. Sci. U.S.A. 80, 2946–2950 (1983).

    Article  ADS  CAS  Google Scholar 

  13. Lomedico, P. T. Proc. natn. Acad. Sci. U.S.A. 79, 5798–5802 (1982).

    Article  ADS  CAS  Google Scholar 

  14. Stacey, D. W., Allfrey, V. G. & Hanafusa, H. Proc. natn. Acad. Sci. U.S.A. 74, 1614–1618 (1977).

    Article  ADS  CAS  Google Scholar 

  15. Schwartz, D. E., Tizard, R. & Gilbert, W. Cell 32, 853–869 (1983).

    Article  CAS  PubMed  Google Scholar 

  16. Griffin, B. E. in DNA Tumor Viruses 2nd edn, 61–124 (Cold Spring Harbor Laboratory, New York, 1981).

    Google Scholar 

  17. Hayward, W. S., Neel, B. G. & Astrin, S. M. Nature 290, 475–480 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Robinson, H. L., Blais, B. M., Tsichlis, P. N. & Coffin, J. M. Proc. natn. Acad. Sci. U.S.A. 79, 1225–1229 (1982).

    Article  ADS  CAS  Google Scholar 

  19. Tsichlis, P. N. et al. Molec cell. Biol. 2, 1331–1338 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Payne, G. S., Bishop, J. M. & Varmus, H. E. Nature 295, 209–214 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  21. Teich, N., Wyke, J., Mak, T., Bernstein, A. & Hardy, W. in RNA Tumor Viruses 2nd edn, 513–648 (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  22. Varmus, H. E., Quintrell, N. & Ortiz, S. Cell 25, 23–36 (1981).

    Article  CAS  PubMed  Google Scholar 

  23. Goubin, G., Goldman, D. S., Luce, J., Neiman, P. E. & Cooper, G. M. Nature 302, 114–119 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  24. Adhya, S. & Gottesman, M. Cell 29, 939–944 (1982).

    Article  CAS  PubMed  Google Scholar 

  25. Hausler, B. & Somerville, R. L. J. molec. Biol. 127, 353–356 (1979).

    Article  CAS  PubMed  Google Scholar 

  26. Horowitz, H. & Platt, T. Nucleic Acids Res. 10, 5447–5465 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Rogers, D. T., Lemire, J. M. & Bostian, K. A. Proc. natn. Acad. Sci. U.S.A. 79, 2157–2161 (1982).

    Article  ADS  CAS  Google Scholar 

  28. Ju, G., Boone, L. & Skalka, A. M. J. Virol. 33, 1026–1033 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Weiss, R. in RNA Tumor Viruses 2nd edn, 209–260 (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  30. Berk, A. J. & Sharp, P. A. Proc. natn. Acad. Sci. U.S.A. 75, 1274–1278 (1978).

    Article  ADS  CAS  Google Scholar 

  31. Weaver, R. F. & Weissmann, C. Nucleic Acids Res. 3, 381–391 (1979).

    Google Scholar 

  32. Luthman, H. & Magnusson, G. Nucleic Acids Res. 11, 1295–1308 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Cullen, B., Lomedico, P. & Ju, G. Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesis. Nature 307, 241–245 (1984). https://doi.org/10.1038/307241a0

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