Several reports describe vector systems capable of producing small interfering RNAs for downregulating gene expression in mammalian cells.
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Tuschl, T. Expanding small RNA interference. Nat Biotechnol 20, 446–448 (2002). https://doi.org/10.1038/nbt0502-446
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DOI: https://doi.org/10.1038/nbt0502-446
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