Recent findings in mice hint that ERβ and not ERα may mediate some of the cardiovascular benefits of estrogen (pages 545–548).
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References
Kuiper, G.G.M.J., Enmark, E., Pelto-Huikko, M., Nilsson, S. & Gustafsson, J-Å. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. USA 93, 5925–5930 (1996).
Kuiper, G.G.M.J. et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptor α and β. Endocrinology 138, 863–870 (1997).
Byers, M., Kuiper, G.G.J.M., Gustafsson, J-Å & Park-Sarge, O-K. Estrogen receptor-β mRNA expression in rat ovary: Down regulation by gonadotropins. Mol. Endocrinol. 11, 172–182 (1997).
Mosselman, S., Polman, J. & Dijkema, R., ERβ: Identification and characterization of a novel human estrogen receptor. FEBS Lett. 392, 49–53 (1996)
Tremblay, G.B. et al. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor β. Mol. Endocrinol. 11, 353–365 (1997).
Shughrue, P.J., Komm, B. & Merchenthaler, I. The distribution of estrogen receptor-beta mRNA in the rat hypothalamus. Steroids 61, 678–681 (1996).
Korach, K.S. et al. Estrogen receptor gene disruption: Molecular characterization and experimental and clinical phenotypes. Recent Prog. HOrm. Res. 51, 159–186 (1996).
lafrati, M.D. et al. Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice. Nature Med. 3, 545–548 (1997).
Wilson, J.D., Griffin, J.E. & Russell, D.W. Steroid 5 alpha-reductase 2 deficiency. Endocr. Rev. 14, 577–593 (1993).
Kruithof-Dekker, I.G., Tetu, B., Janssen, P.J. & Vander Kwast, T.H. Elevated estrogen receptor expression in human prostatic stromal cells by androgen ablation therapy. J. Urol. 156, 1194–1197 (1996).
Katzenellenbogen, B.S. et al. Antiestrogens: Mechanisms and actions in target cells. J. Steroid Biochem. Mol. Biol. 53, 387–393 (1995).
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Gustafsson, JÅ. Estrogen receptor β — Getting in on the action?. Nat Med 3, 493–494 (1997). https://doi.org/10.1038/nm0597-493
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DOI: https://doi.org/10.1038/nm0597-493
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