Issue 12, 2009

Global signatures of protein and mRNA expression levels

Abstract

Cellular states are determined by differential expression of the cell’s proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.

Graphical abstract: Global signatures of protein and mRNA expression levels

Article information

Article type
Review Article
Submitted
27 Apr 2009
Accepted
22 Jul 2009
First published
01 Oct 2009

Mol. BioSyst., 2009,5, 1512-1526

Global signatures of protein and mRNA expression levels

R. de Sousa Abreu, L. O. Penalva, E. M. Marcotte and C. Vogel, Mol. BioSyst., 2009, 5, 1512 DOI: 10.1039/B908315D

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