Issue 11, 2003
From the journal:

Organic & Biomolecular Chemistry

Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators

Toshie Fujishima,a   Atsushi Kittaka,a   Kazuyoshi Yamaoka,b   Ken-ichi Takeyama,b   Shigeaki Katob  and  Hiroaki Takayama*a  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-0195, Japan

b Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032, Japan

Abstract

A concise synthesis of all four possible A-ring stereoisomers of 2,2-dimethyl-1,25-dihydroxyvitamin D3 and characterization of their distinct transcriptional features, which appear to have been inherited from the corresponding 2α-methyl derivatives, is reported.

Graphical abstract: Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators

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Article information

DOI
https://doi.org/10.1039/B302017G
Article type
Paper
Submitted
24 Feb 2003
Accepted
02 Apr 2003
First published
17 Apr 2003

Org. Biomol. Chem., 2003,1, 1863-1869

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Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators

T. Fujishima, A. Kittaka, K. Yamaoka, K. Takeyama, S. Kato and H. Takayama, Org. Biomol. Chem., 2003, 1, 1863 DOI: 10.1039/B302017G

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