Issue 3, 1991

Mechanistic studies on pregnene side-chain cleavage enzyme (17α-hydroxylase-17,20-lyase) using 18O

Abstract

In the conversion of pregnenolone 1 into dehydroisoandrosterone 3 and 3β-hydroxyandrosta-5,16-diene 5 an atom of oxygen from O2 is incorporated into the side chain released as acetate; during the conversions the C-21 methyl hydrogens of the precursor are not disturbed, the status of 16α and 17α hydrogen atoms during the conversions is also defined.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1991, 157-159

Mechanistic studies on pregnene side-chain cleavage enzyme (17α-hydroxylase-17,20-lyase) using 18O

S. L. Miller, J. N. Wright, D. L. Corina and M. Akhtar, J. Chem. Soc., Chem. Commun., 1991, 157 DOI: 10.1039/C39910000157

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