Issue 11, 1991

The mechanism of cytochrome P-450 dependent C–C bond cleavage: studies on 17α-hydroxylase-17,20-lyase

Abstract

It is shown that formation of 17α-hydroxyandrost-5-en-3β-ol from pregnenolone occurs solely at the expense of the cleavage of the C-17–C-20 bond of the precursor and is best rationalised by invoking the participation of an FeIII–OOH intermediate in the acyl–carbon fission process.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1991, 782-783

The mechanism of cytochrome P-450 dependent C–C bond cleavage: studies on 17α-hydroxylase-17,20-lyase

D. L. Corina, S. L. Miller, J. N. Wright and M. Akhtar, J. Chem. Soc., Chem. Commun., 1991, 782 DOI: 10.1039/C39910000782

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