Regular ArticlesHypoxia Attenuates PGE2but Increases Prostacyclin and Thromboxane Production in Human Term Villous Trophoblast
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Cited by (18)
Phosphodiesterase-5 inhibitors and omental and placental small artery function in normal pregnancy and pre-eclampsia
2006, European Journal of Obstetrics and Gynecology and Reproductive BiologyProstaglandin E<inf>2</inf> Inhibits Proliferation and Migration of HTR-8/SVneo Cells, a Human Trophoblast-derived Cell Line
2006, PlacentaCitation Excerpt :Moreover, a highly invasive phenotype, possibly produced by a decrease of cAMP production, has been observed in keratinocytes lacking the EP2 receptor [47]. Our results demonstrating an inhibitory role of PGE2 in the modulation of EVT cell functions allow to hypothesize that the enhanced proliferation observed in hypoxia [1,9] could be due to a reduction of the prostanoid production, as demonstrated by Blumenstein et al. [48] in hypoxic trophoblast cells. In addition, our data are in line with the observation that an enhancement of COX-2 expression and activity occurs in placental villi obtained from preeclamptic women [49].
Increased phospholipase A<inf>2</inf> and thromboxane but not prostacyclin production by placental trophoblast cells from normal and preeclamptic pregnancies cultured under hypoxia condition
2005, PlacentaCitation Excerpt :According to this theory, an immune maladaptation and deficient placental implantation are believed to lead to the failure of the physiological remodeling of uterine spiral arteries. These deficiencies in placentation may lead to focal regions of hypoxia that, in turn, is thought to alter the productions of growth factors, cytokines [4], lipid peroxides [5], and prostaglandins such as thromboxane (TX) and prostacyclin (PGI2) by placental trophoblast cells [6]. TX is a vasoconstrictor and PGI2 is a vasodilator.
Prostaglandin synthases: Recent developments and a novel hypothesis
2004, Prostaglandins Leukotrienes and Essential Fatty AcidsNuclear prostaglandin receptors: Role in pregnancy and parturition?
2004, Prostaglandins Leukotrienes and Essential Fatty Acids
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