Elsevier

Placenta

Volume 23, Supplement A, April 2002, Pages S159-S164
Placenta

Regular Articles
Mechanisms of Drug Transfer Across the Human Placenta—A Workshop Report

https://doi.org/10.1053/plac.2002.0821Get rights and content

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    • Effects of single and repetitive valproic acid administration on the gene expression of placental transporters in pregnant rats: An analysis by gestational period

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      Human MRP5 (ABCC5) have been shown to be expressed in the basolateral membrane of the syncytiotrophoblast [32], whereas its localization in the rat placenta remains unclear. It has been reported that rat Octn1, 2 (Slc22a4, 5) is expressed in the apical membrane [65]. Human LAT1, 2 (SLC7A5, 8) have been reported to be present on the apical side of the syncytiotrophoblast, whereas LAT2 is also expressed in the basolateral membrane and in the fetal capillary endothelium [44].

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      In the placenta, OATs and OATPs mediate transport of metabolites such as steroid sulphates, thyroid hormones and prostaglandins as well as transport of waste products and xenobiotics. In the human placenta OATP4A1 (SLC04A1) and OATP2A1 (SLC02A1) are expressed on the maternal facing microvillous membrane and OAT4 and OATP2B1 on the fetal facing basal membrane of the placental syncytiotrophoblast [2,3]. OATs and OATPs are typically exchange transport proteins that transport a substrate together with the reverse transport of a counter-ion.

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      But prior to enzymatic conversion, these sulfated steroids must enter the cells by carrier mediated transport. Although information on carriers for uptake and release of organic compounds in the human placenta significantly increased during the last decade [63,150,83,10,163], the carrier-mediated supply of syncytiotrophoblasts with sulfated C-19 steroids is not fully understood. DHEAS uptake into the human placenta was already investigated in cytotrophoblasts, choriocarcinoma cell lines, BHK cells and BHK cells transfected with human STS (BHK-STS cells) in suspension [160].

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    To whom correspondence should be addressed at: Division of Clinical Pharmacology, University Hospital Zürich, Ramistrasse 100, Zürich, Switzerland. Tel: 41 1 255 3009; Fax: 41 1 255 4411; E-mail: [email protected]

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