Regular ArticlesMechanisms of Drug Transfer Across the Human Placenta—A Workshop Report
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Cited by (30)
Effects of single and repetitive valproic acid administration on the gene expression of placental transporters in pregnant rats: An analysis by gestational period
2020, Reproductive ToxicologyCitation Excerpt :Human MRP5 (ABCC5) have been shown to be expressed in the basolateral membrane of the syncytiotrophoblast [32], whereas its localization in the rat placenta remains unclear. It has been reported that rat Octn1, 2 (Slc22a4, 5) is expressed in the apical membrane [65]. Human LAT1, 2 (SLC7A5, 8) have been reported to be present on the apical side of the syncytiotrophoblast, whereas LAT2 is also expressed in the basolateral membrane and in the fetal capillary endothelium [44].
Transplacental transfer mechanism of organochlorine pesticides: An in vitro transcellular transport study
2020, Environment InternationalEstrone sulphate uptake by the microvillous membrane of placental syncytiotrophoblast is coupled to glutamate efflux
2018, Biochemical and Biophysical Research CommunicationsCitation Excerpt :In the placenta, OATs and OATPs mediate transport of metabolites such as steroid sulphates, thyroid hormones and prostaglandins as well as transport of waste products and xenobiotics. In the human placenta OATP4A1 (SLC04A1) and OATP2A1 (SLC02A1) are expressed on the maternal facing microvillous membrane and OAT4 and OATP2B1 on the fetal facing basal membrane of the placental syncytiotrophoblast [2,3]. OATs and OATPs are typically exchange transport proteins that transport a substrate together with the reverse transport of a counter-ion.
The role of sulfated steroid hormones in reproductive processes
2017, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :But prior to enzymatic conversion, these sulfated steroids must enter the cells by carrier mediated transport. Although information on carriers for uptake and release of organic compounds in the human placenta significantly increased during the last decade [63,150,83,10,163], the carrier-mediated supply of syncytiotrophoblasts with sulfated C-19 steroids is not fully understood. DHEAS uptake into the human placenta was already investigated in cytotrophoblasts, choriocarcinoma cell lines, BHK cells and BHK cells transfected with human STS (BHK-STS cells) in suspension [160].
Therapeutic drug monitoring of intracellular anti-infective agents
2014, Journal of Pharmaceutical and Biomedical AnalysisPlacental Metabolism of Xenobiotics
2010, Comprehensive Toxicology, Second Edition
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