Regular ArticleDrug treatment of microsporidiosis
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Cited by (66)
Enterocytozoon bieneusi of animals—With an ‘Australian twist’
2021, Advances in ParasitologyCitation Excerpt :Albendazole inhibits microsporidian division by blocking the synthesis of tubulin during the process of mitosis (Conteas et al., 2000; Costa and Weiss, 2000; Desportes-Livage and Datry, 2005). This compound is used, for example, to treat Encephalitozoon infections in HIV patients (Bednarska et al., 2013; Didier et al., 2004), with rare side effects (Costa and Weiss, 2000; Groß, 2003). This drug appears to have a parasitostatic effect on E. bieneusi (see Blanshard et al., 1993; Conteas et al., 2000; Costa and Weiss, 2000; Didier, 2005; Didier et al., 2004; Horton, 2002) and it alleviates clinical signs (i.e. decreased defaecation frequency and volume in infected individuals) (Dieterich et al., 1994), but symptom-relapses are common following treatment (Blanshard et al., 1993; Costa and Weiss, 2000).
Hemocytin facilitates host immune responses against Nosema bombycis
2020, Developmental and Comparative ImmunologyCitation Excerpt :Nowadays, more than 1400 species have been identified, around 700 species can infect insects and over 17 species in 9 genera are known to infect humans, especially immune-deficient individuals (Cali et al., 2005; Vavra and Lukes, 2013; Weiss, 1995). Although there are many studies about the host immune response against microsporidia, the involvement of hemocytin in the process has not been reported so far (Akiyoshi et al., 2007; Bacchi et al., 2002; Cislakova and Halanova, 2003; Costa and Weiss, 2000). Our study found that the expression and secretion of hemocytin were significantly up-regulated in silkworms after infection with N. bombycis, indicating that hemocytin in the silkworms responded to the invasion of N. bombycis.
Symptomatic respiratory Encephalitozoon cuniculi infection in renal transplant recipients
2019, International Journal of Infectious DiseasesCitation Excerpt :However, the importance of proper diagnosis is highlighted by the fact that the treatment of microsporidia is limited and genus-specific. In the treatment of human microsporidiosis, albendazole and fumagillin are known to have the highest clinical efficacy (Costa and Weiss, 2000; Champion et al., 2010). Albendazole is the drug of choice for the treatment of intestinal, respiratory, and disseminated microsporidiosis caused by Encephalitozoon spp., but has limited efficacy against E. bieneusi (Costa and Weiss, 2000).
Respiratory microsporidiosis caused by Enterocytozoon bieneusi in an HIV-negative hematopoietic stem cell transplant recipient
2018, International Journal of Infectious DiseasesCitation Excerpt :Since fumagillin is not registered for human treatment in Poland and albendazole appears to be well-tolerated in immunocompromised patients, this drug was administered to the patient in the present case report. Nevertheless, treatment with albendazole has been shown to result in clinical improvement in up to 50% of patients infected with E. bieneusi in some studies (Costa and Weiss, 2000). Moreover, the presence of E. bieneusi persisted during treatment in all patients, but a decrease in pathogen burden has been observed (Dieterich et al., 1994).