Planta Med 2010; 76(16): 1896-1900
DOI: 10.1055/s-0030-1249934
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Pterosins from Pteris multifida

Dan-Wei Ouyang1 , Xiang Ni1 , Hai-Yan Xu1 , Jia Chen1 , Pei-Ming Yang1 , De-Yun Kong1
  • 1Department of Chinese Traditional Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, P. R. China
Further Information

Publication History

received June 28, 2009 revised March 24, 2010

accepted April 15, 2010

Publication Date:
19 May 2010 (online)

Abstract

A new C14 pterosin sesquiterpenoid, named (2R)-pterosin P (1), and a new natural product, named dehydropterosin B (3), were isolated from the aerial parts of Pteris multifida Poir., along with nine known compounds (2, 411). By chiral HPLC, compounds 1 and 2 were isolated as a pair of enantiomeric pterosin sesquiterpenoids. The planar structure of 1 was elucidated on the basis of NMR spectroscopy analysis, and the absolute configuration was established by the CD spectrum. In addition, the absolute structure of 1 was further confirmed by single-crystal X-ray diffraction (CuKα). Compounds 3, 5, and 6 showed potent cytotoxicity against PANC-1 (human pancreatic cancer) and NCI-H446 (human small-cell lung cancer) cell lines, with IC50 values in the range of 4.27–14.63 µM.

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Prof. Pei-Ming Yang

Department of Chinese Traditional Medicine
Shanghai Institute of Pharmaceutical Industry

1320 West Beijing Road

Shanghai 200040

People's Republic of China

Phone: + 86 21 62 47 98 08 ext. 4 63

Fax: + 86 21 62 79 01 48

Email: yangpeiming@yahoo.cn

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