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Planta Med 2012; 78(13): 1490-1514
DOI: 10.1055/s-0031-1298331
Examples of Herb-Drug Interactions
Reviews
© Georg Thieme Verlag KG Stuttgart · New York

Pharmacokinetic Herb-Drug Interactions (Part 2): Drug Interactions Involving Popular Botanical Dietary Supplements and Their Clinical Relevance

Bill J. Gurley1 , Espero Kim Fifer2 , Zoë Gardner2
  • 1Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, AR, USA
  • 2Department of Plant, Soil & Insect Sciences, University of Massachusetts, Amherst, MA, USA
Further Information

Publication History

received Dec. 22, 2011 revised February 6, 2012

accepted February 10, 2012

Publication Date:
07 May 2012 (online)

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Abstract

In Part 2 of this review, a critical examination of the pertinent scientific literature is undertaken in order to assess the interaction risk that popular dietary supplements may pose when taken concomitantly with conventional medications. Botanicals most likely to produce clinically important herb-drug interactions are those whose phytochemicals act as mechanism-based inhibitors of cytochrome P450 enzyme activity (e.g., Hydrastis canadensis, Piper nigrum, Schisandra chinensis) or function as ligands for orphan nuclear receptors (e.g., Hypericum perforatum). In addition, several external factors unrelated to phytochemical pharmacology can augment the drug interaction potential of botanical supplements.

Key Words

herb-drug interaction - plant secondary metabolites - cytochrome P450 enzymes - transferases - ATP-binding cassette transporters - solute carrier membrane transport proteins - botanical dietary supplements - black cohosh - Echinacea - garlic - Ginkgo biloba - ginseng - goldenseal - kava - black pepper - piperine - Schisandra - milk thistle - St. John's wort - methylenedioxyphenyl-containing compounds

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Dr. Bill Gurley

Department of Pharmaceutical Sciences
UAMS, College of Pharmacy

4301 W. Markham St.

Little Rock, AR 72205

United States

Phone: +1 50 16 86 62 79

Fax: +1 50 15 26 65 10

Email: gurleybillyj@uams.edu

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