Am J Perinatol 2012; 29(10): 777-786
DOI: 10.1055/s-0032-1316447
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Marinobufagenin Predicts and Resibufogenin Prevents Preeclampsia: A Review of the Evidence

Jules B. Puschett
1   Department of Pathobiology, Texas A&M College of Veterinary Medicine and Biomedical Sciences, College Station and Houston, Texas
› Author Affiliations
Further Information

Publication History

26 January 2012

13 March 2012

Publication Date:
16 July 2012 (online)

Abstract

Objective The purpose of this review is to provide information detailing the existing evidence with regard to the hypothesis that marinobufagenin (MBG) is an important etiologic and predictive factor in preeclampsia (PE). In addition, evidence describing the role of the antagonist to MBG, resibufogenin (RBG), in the prevention and/or treatment of this disorder is provided.

Study Design The studies outlined were performed in an animal model of PE, in in vitro experiments, and in human studies.

Results Data have been obtained that strongly support the hypothesis that ~60 to 70% of PE patients demonstrate elevations in urinary and serum MBG levels. In the animal model, the entire syndrome can be prevented by the administration of RBG beginning early in pregnancy.

Conclusion Expanded human trials of MBG as a predictor of the later development of PE are warranted as are studies of the efficacy and safety of RBG as a preventative/therapy.

 
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