In Vitro Neuroprotective Activities of Phenylethanoid Glycosides from Callicarpa dichotoma

 

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Abstract

Ten phenylethanoid glycosides, forsythoside B, acteoside, 2′-acetylacteoside, poliumoside, brandioside, echinacoside, isoacteoside, cistanoside H and E-tubuloside E as well as a new compound, Z-tubuloside E, were isolated from the n-BuOH fraction of Callicarpa dichotoma Raeuschel (Verbenaceae) by bioactivity-guided fractionation using glutamate-injured primary cultures of rat cortical cells as a screening system. These phenylethanoid glycosides significantly attenuated glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM.

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Young Choong Kim, PH.D.

College of Pharmacy

Seoul National University

San 56-1

Shillim-Dong

Kwanak-Gu

Seoul 151-742

Korea

Phone: +82-2-880-7842

Fax: +82-2-888-2933

Email: youngkim@ snu.ac.kr

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