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Planta Med 2006; 72(9): 854-856
DOI: 10.1055/s-2006-946639
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Quinolizidine Alkaloids with Anti-HBV Activity from Sophora tonkinensis

Pei-Lan Ding1 , Hai Huang2 , Pei Zhou2 , Dao-Feng Chen1
  • 1Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, P. R. China
  • 2Department of Biosynthetic Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, P. R. China
Further Information

Publication History

Received: January 14, 2006

Accepted: April 29, 2006

Publication Date:
19 June 2006 (online)

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Abstract

A new matrine-type alkaloid, (-)-14β-hydroxyoxymatrine (1), was isolated from the roots and rhizomes of Sophora tonkinensis Gapnep. (Leguminosae), together with five known matrine-type alkaloids, (-)-14β-hydroxymatrine (2), (+)-oxymatrine (3), (+)-matrine (4), (+)-sophoranol (5), and (-)-5α-hydroxysophocarpine (6), as well as with two known cytisine-type alkaloids, (-)-cytisine (7) and (-)-N-methylcytisine (8). Their structures were elucidated by spectroscopic methods. Compounds 1, 5 and 7 showed potent anti-HBV activity with an inhibitory potency against HBsAg secretion of 22.6 %, 31.1 % and 33.2 %, and against HBeAg secretion of 30.4 %, 26.3 % and 27.8 %, respectively.

References

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Dr. Dao-Feng Chen

Department of Pharmacognosy

School of Pharmacy

Fudan University

138 Yi Xue Yuan Road

Shanghai 200032

People’s Republic of China

Phone: +86-21-5423-7453

Fax: +86-21-6417-0921

Email: dfchen@shmu.edu.cn

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