Original Article
Phenothiazine Phototoxicity: an Experimental Study on Chlorpromazine and its Metabolites

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Chlorpromazine (CPZ) metabolites were studied for their phototoxic potency with the mouse tail technique. The demethylated metabolites were more phototoxic than CPZ, while CPZ-sulfoxide, 7-hydroxy-CPZ, and 2-chlorphenothiazine were less phototoxic. The phototoxicity of CPZ and desmethyl-CPZ preexposed to UVA was lost, while that of CPZ-sulfoxide was retained. By thin-layer chromatography, CPZ-sulfoxide and promazine were identified as photoproducts of CPZ; the sulfoxide was fairly stable to radiation.

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