Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Metabolism of Ginsenoside Rc by Human Intestinal Bacteria and Its Related Antiallergic Activity
Eun-Ah BaeMin-Kyung ChooEun-Kyung ParkSun-Young ParkHo-Young ShinDong-Hyun Kim
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2002 Volume 25 Issue 6 Pages 743-747

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Abstract

When ginsenoside Rc was anaerobically incubated with human fecal microflora, all specimens metabolized ginsenoside Rc to compound K and protopanaxadiol. The main metabolite was compound K. Among the bacteria isolated from human fecal microflora, most bacteria, such as Bacteroides sp., Eubacterium sp., and Bifidobacterium sp. potently transformed ginsenoside Rc to compound K. Bifidobacterium K-103 and Eubacterium A-44 transformed it to compound K via ginsenoside Rd, and Bacteroides HJ-15 and Bifidobacterium K-506 metabolized to compound K via ginsenoside Mb, which was isolated as a new metabolite (M.W. 940[+Na]). Among ginsenoside Rc and its metabolites, compound K exhibited the most potent antiallergic activity on the IgE-induced RBL cell line as well as potent cytotoxic activity against tumor cell lines.

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© 2002 The Pharmaceutical Society of Japan
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