Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
Gambogenic Acid Inhibits Proliferation of A549 Cells through Apoptosis-Inducing and Cell Cycle Arresting
Qinglin Li, Hui Cheng, Guoqi Zhu, Li Yang, An Zhou, Xiaoshan Wang, Nianbai Fang, Lunzhu Xia, Jingjing Su, Mei Wang, Daiying Peng, Qi Xu
Author information
Keywords: gambogenic acid, anticancer effect, apoptosis, cell cycle
JOURNAL FREE ACCESS

2010 Volume 33 Issue 3 Pages 415-420

Details
Download PDF (1618K)
Download citation RIS

(compatible with EndNote, Reference Manager, ProCite, RefWorks)

BIB TEX

(compatible with BibDesk, LaTeX)

Text
How to download citation
Contact us
Abstract

Although anticancer effect of gambogic acid (GA) and its potential mechanisms were well documented in past decades, limited information is available on the anticancer effect of gambogenic acid (GNA), another major active component of Gamboge. Here we performed a study to determine whether GNA possesses anticancer effect and find its potential mechanisms. The results suggested that GNA significantly inhibited the proliferation of several tumor cell lines in vitro and in vivo. Treatment with GNA dose and time dependently induced A549 cells apoptosis, arrested the cells to G0/G1 phase in vitro and down-regulated the expression of cyclin D1 and cyclooxygenase (COX)-2 in mRNA level. In addition, anticancer effect was further demonstrated by applying xenografts in nude mice coupled with the characteristic of apoptosis in the GNA treated group. Taken together, these observations might suggest that GNA inhibits tumor cell proliferation via apoptosis-induction and cell cycle arrest.

Content from these authors
© 2010 The Pharmaceutical Society of Japan
Previous article Next article
Favorites & Alerts

Recently viewed articles
Share this page
feedback
 Top