Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
THE β-GLUCOSIDATION AND β-GLUCURONIDATION OF PANTOTHENIC ACID COMPARED WITH P-NITROPHENOL IN DOG LIVER MICROSOME
Kozaburo NakanoMotoaki OhashiShoichi Harigaya
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1986 Volume 34 Issue 9 Pages 3949-3952

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Abstract

The β-glucosidation and β-glucuronidation of pantothenic acid (PaA) in dog liver microsome were compared with those of p-nitrophenol. PaA underwent β-glucosidation in the presence of uridine diphosphate glucose (UDPG). However, p-nitrophenol did not conjugate β-glucose but underwent β-glucuronidation in the presence of uridine diphosphate glucuronic acid (UDPGA). The UDP-glucuronyltransferase effect on p-nitrophenol was 1000 times larger than the UDP-glucosyltransferase effect on PaA. But no glucuronidation of PaA occurred. The optimum pH for the glucosidation of PaA was 8.5. These results indicate that PaA has a high specificity for β-glucosidation, and that β-glucosidation is an essential pathway in the metabolism of PaA in dogs.

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© The Pharmaceutical Society of Japan
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