Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Original
Distribution and Properties of Rat Intestinal Alkaline Phosphatase Isoenzymes
Hiroshi WADAIkuo YAGAMINoboru NIWATakashi HAYAKAWAHaruhito TSUGE
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JOURNAL FREE ACCESS

2001 Volume 50 Issue 2 Pages 153-158

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Abstract

The ALP activities and properties of rat intestine cut into 20 segments were examined, and we were able to demonstrate that the ALP activity of upper intestine is high compared to that of lower intestine. This result coincided with those of other reports. However, we newly clarified that there is an ALP isoenzyme found in the lower intestine which can be inhibited by L-homoarginine. The molecular weight of the ALP isoenzyme was 136 kDa. In addition, it was clarified that there are several isoenzymes from upper to lower intestine. This study demonstrates that there exist isoenzymes, which are inhibited by L-HArg, in the intestine which are similar to the isoenzymes in the liver, bone and kidney.

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© 2001 Japanese Association for Laboratory Animal Science
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