Regular ArticleFunction of Uptake Transporters for Taurocholate and Estradiol 17β-D-Glucuronide in Cryopreserved Human Hepatocytes
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Recent advances in preclinical in vitro approaches towards quantitative prediction of hepatic clearance and drug-drug interactions involving organic anion transporting polypeptide (OATP) 1B transporters
2020, Drug Metabolism and PharmacokineticsCitation Excerpt :Human hepatocytes are the gold standard as a source of in vitro systems because they are expected to have intact cell functions, including transporter-mediated drug uptake. Freshly prepared and cryopreserved human hepatocytes are currently available from commercial sources; however, large interbatch differences in the activities of hepatic uptake transporters, including OATP1Bs, are common issues [25,26]. It remains to be clarified whether the considerable interbatch differences observed in vitro truly reflect intersubject differences in vivo or are just artifacts produced by the storage of human liver tissues and the hepatocyte isolation process.
Comparison of mRNA expression profiles of drug-metabolizing enzymes and transporters in fresh and cryopreserved cynomolgus monkey hepatocytes
2019, Drug Metabolism and PharmacokineticsA critical assessment of in vitro tissue models for ADME and drug delivery
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- a
Current address: Faculty of Pharmaceutical Sciences, Showa University, Tokyo, Japan
- b
Current address: Phase-1 Molecular Toxicology, Inc., Santa Fe, NM, USA
- c
Current address: Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
- d
Current address: Millennium Pharmaceuticals Inc., Cambridge, MA, USA