ReviewMetabolic and Non-Metabolic Factors Determining Troglitazone Hepatotoxicity: A Review
References (68)
Lessons from the glitazones: a story of drug development
Lancet
(2001)- et al.
Troglitazone-induced liver failure: a case study
Am. J. Med.
(2003) - et al.
Drug-induced liver injury: mechanisms and test systems
Hepatology
(2001) - et al.
Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction
Biochem. Pharmacol.
(2001) - et al.
Identification of glutathione conjugates of troglitazone in human hepatocytes
Chem. Biol. Interact.
(2002) - et al.
Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxicity to HepG2 cells
Drug Metab. Dispos.
(2002) - et al.
Toxic effect of troglitazone on cultured rat hepatocytes
Life Sci.
(2001) - et al.
Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells
Life Sci.
(2001) - et al.
Correlation between troglitazone cytotoxicity and drug metabolic enzyme activities in cryopreserved human hepatocytes
Chem. Biol. Interact.
(2002) - et al.
An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics
Toxicology
(2005)
Hepatotoxicity of the thiazolidinediones
Clin. Liver Dis.
(2003)
Differential in vitro hepatotoxicity of troglitazone and rosiglitazone among cryopreserved human hepatocytes from 37 donors
Chem. Biol. Interact.
(2002)
Identification of in vitro protein biomarkers of idiosyncratic liver toxicity
Toxicol. In Vitro
(2004)
The development of a higher throughput reactive intermediate screening assay incorporating micro-bore liquid chromatography-micro-electrospray ionization-tandem mass spectrometry and glutathione ethyl ester as an in vitro conjugating agent
J. Pharm. Biomed. Anal.
(2004)
Troglitazone but not rosiglitazone induces G1 cell cycle arrest and apoptosis in human and rat hepatoma cell lines
Toxicol. Lett.
(2003)
Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro
Mutat. Res.
(2004)
Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes
Hepatology
(2003)
Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells
Toxicol. Lett.
(2005)
The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death
Biochim. Biophys. Acta
(1996)
The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy
Biochim. Biophys. Acta
(1998)
Role of mitochondrial permeability transition in diclofenacinduced hepatocyte injury in rats
Hepatology
(2002)
Involvement of mitochondrial permeability transition in acetaminopheninduced liver injury in mice
J. Hepatol.
(2005)
Mitochondrial permeability transition as a potential determinant of hepatotoxicity of antidiabetic thiazolidinediones
Toxicology
(2006)
PPAR: a mediator of peroxisome proliferator action
Mutat. Res.
(1995)
Diabetic KKAy mice exhibit increased hepatic PPARγ1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones
J. Hepatol.
(2001)
Toxicological consequences of altered peroxisome proliferator-activated receptor γ (PPARγ) expression in the liver: insights from models of obesity and type 2 diabetes
Biochem. Pharmacol.
(2002)
Thiazolidinediones: Pleiotropic drugs with potent anti-inflammatory properties for tissue protection
Hepatol. Res.
(2005)
Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met
Gastroenterology
(2004)
Downregulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetes
Biochem. Pharmacol.
(2000)
Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease
Biochem. Biophys. Res. Commun.
(2003)
Troglitazoneinduced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate
Toxicology
(2001)
Hepatic dysfunction associated with troglitazone
N. Engl. J. Med.
(1998)
Mechanisms of troglitazone hepatotoxicity
Chem. Res. Toxicol.
(2003)
Troglitazone and liver injury: in search of answers
Hepatology
(2005)
Cited by (0)
Copyright © 2006 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.