Regular ArticlePrediction of Human Disposition toward S-3H-Warfarin using Chimeric Mice with Humanized Liver
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Genetically Humanized Animal Models
2017, Comprehensive Medicinal Chemistry IIIEffect of impaired renal function on the maintenance dose of warfarin in Japanese patients
2015, Journal of CardiologyCitation Excerpt :Recently, a growing body of evidence suggests that the pharmacokinetics and pharmacodynamics of drugs that are eliminated primarily by metabolic processes in the liver are also altered by compromised renal function, leading to significant reductions in nonrenal clearance of such drugs [1–4]. Warfarin is eliminated through hepatic metabolism and not directly excreted by the kidney [5–8]. However, when treated with warfarin, patients with chronic renal impairment have higher risk of both hemorrhagic [29–33] and ischemic [34,35] events than those with normal renal function.
Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice
2012, PhytomedicineCitation Excerpt :This may also have contributed to the unclear influence of bilobalide on (S)-warfarin concentration. Species differences exist in warfarin metabolism; (S)-warfarin is mainly metabolized to (S)-7-hydroxywarfarin in humans and to (S)-4-hydroxywarfarin with some (S)-7-hydroxywarfarin in mice (Inoue et al. 2009). In the present study, it is difficult to extrapolate the findings to how GBE and bilobalide influence the pharmacokinetics of warfarin in humans.
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