SNP CommunicationGenetic Variations of the ABC Transporter Gene ABCB11 Encoding the Human Bile Salt Export Pump (BSEP) in a Japanese Population
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2020, ChemosphereCitation Excerpt :One of the primary function of liver is to produce and secrete bile, which is essential for solubilizing and absorbing dietary lipids (Lam et al., 2010). The bile salt export pump (BSEP) is an ATP-binding bile salt transporter responsible for the secretion of bile salts across the canalicular membrane (Kim et al., 2009). Inhibition of BSEP can result in accumulation of bile salts in the liver, which is considered to be a primary reason for drug-induced liver injury (DILI) (Kosters and Karpen, 2008).
Role of membrane transport in hepatotoxicity and pathogenesis of drug-induced cholestasis
2013, Drug-Induced Liver DiseaseThe bile salt export pump (BSEP) in health and disease
2012, Clinics and Research in Hepatology and GastroenterologyHepatic overexpression of abcb11 promotes hypercholesterolemia and obesity in mice
2011, GastroenterologyThe ESCRT-III molecules regulate the apical targeting of bile salt export pump
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As of February 9, 2009, the novel variations reported here are not found in the database of Japanese Single Nucleotide Polymorphisms (http://snp.ims.u-tokyo.ac.jp/), dbSNP in the National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov/SNP/), or the PharmGKB Database (http://www.pharmgkb.org/).
This study was supported in part by the Program for the Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation, and the Health and Labor Sciences Research Grants from the Ministry of Health, Labor and Welfare.