Regular ArticleElevated Systemic Elimination of Cimetidine in Rats with Acute Biliary Obstruction: The Role of Renal Organic Cation Transporter OCT2
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Bile duct ligation differently regulates protein expressions of organic cation transporters in intestine, liver and kidney of rats through activation of farnesoid X receptor by cholate and bilirubin
2023, Acta Pharmaceutica Sinica BCitation Excerpt :Several studies have demonstrated that liver injury alters expressions of OCTs in liver and kidney, which are dependent on type of liver failure and OCT species. For example, liver injury induced by ischemia‒reperfusion downregulates expressions of renal Oct2 and Mate1, leading to decreases in systemic and tubular secretory clearance of cimetidine20. Significant downregulation of hepatic Oct1 and renal Oct2 are also observed in ethynylestradiol-induced cholestasis rats19.
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2019, Journal of Pharmaceutical SciencesCitation Excerpt :The increased expression of Oct2 suggests that the renal clearance of pindolol, and other substrates of this cationic transporter, would be increased in AD. A previous study has reported that the renal expression and function of Oct2 were significantly increased in rats with acute biliary obstruction,28 suggesting that the increase in renal Oct2 we observed in APP/PS1 mice may also result from increased plasma concentrations of bile acids, as described for Mrp2. Proteomic analysis also identified a significant increase in the expression of Oat3, a solute-linked carrier protein expressed at the basolateral membrane of renal proximal tubular epithelial cells.
JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats
2013, Toxicology and Applied PharmacologyCitation Excerpt :Mannitol is a diuretic agent, commonly used in the perioperative setting due to its renoprotective properties. It is freely filtered in the glomerulus and due to its limited reabsorption it creates sufficient osmotic force in the kidney tubules to inhibit the reabsorption of fluids and solutes along the nephron (Bengt et al., 2009; Kurata et al., 2010; Robert et al., 2004). PEPT2 is localized at the brush-border membranes of proximal tubules, and mediates the reabsorption of dipeptides and ACEIs, such as JBP485 and lisinopril (Guo et al., 2012a, 2012b).
This work was supported by the Japan Society for the Promotion of Science [Grant-in-Aid for Scientific Research (C) 20590143].