Skip to main content
SpringerLink
Log in

Cerebrospinal Fluid Pharmacokinetics of the Antituberculosis Drugs

Influence of Age and Phenobarbitone Co-Medication

  • Short Communication
  • Published:
Clinical Pharmacokinetics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Anderson, D.G. and Jewell, M.: The absorption, excretion and toxicity of streptomycin in man. New England Journal of Medicine 233: 485–491 (1945).

    Article  Google Scholar 

  • Barclay, W.R.: Eben, R.H.: LeRoy, G.V.: Manthei, R.W. and Roth, L.J.: Distribution and excretion of radioactive isoniazid in tuberculous patients. Journal of the American Medical Association 151: 1384–1388 (1953).

    PubMed  CAS  Google Scholar 

  • Bobrowitz, I.D.: Ethambutol in tuberculous meningitis. Chest 61: 629–632 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Boger, W.P. and Gavin, J.J.: Kanamycin: Its cerebrospinal fluid diffusion, renal clearance and comparison with streptomycin. Antibiotics Annual — 1958-1959: 677–683 (1959).

    Google Scholar 

  • D’Oliveira, J.J.G.: Cerebrospinal fluid concentrations of rifampin in meningeal tuberculosis. American Review of Respiratory Disease 106: 432–437 (1972).

    PubMed  Google Scholar 

  • Eichenwald, H.F.: Some observations on dosage and toxicity of kanamycin in premature and full term infants. Annals of the New York Academy of Sciences 132: 984–991 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Elmendorf, D.F.: Cawthon, W.U.: Muschenheim, C. and Mc-Dermott, W.: The absorption, distribution, excretion and short term toxicity of isonicotinic acid hydrazide (Nydrazid) in man. American Review of Tuberculosis 65: 429–442 (1952).

    PubMed  CAS  Google Scholar 

  • Forgan-Smith, R.: Ellard, G.A.: Newton, D. and Mitchison, D.A.: Pyrazinamide and other drugs in tuberculosis meningitis. Lancet 2: 374 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Gundert-Remy, U.: Klett, M. and Weber, E.: Concentration of ethambutol in cerebrospinal fluid in man as a function of the non-protein bound drug fraction in serum. European Journal of Clinical Pharmacology 6: 133–136 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Heilman, D.H.: Heilman, F.R.: Hinshaw, H.C.: Nicholas, D.R. and Herreil, W.E.: Streptomycin: Absorption, diffusion, excretion and toxicity. American Journal of Medical Science 210: 576–584 (1945).

    Article  CAS  Google Scholar 

  • Holdiness, MR.: Clinical pharmacokinetics of the antituberculosis drugs. Clinical Pharmacokinetics 9: 511–544 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Hughes, I.E. and Smith, H.: Ethionamide: Its passage into the cerebrospinal fluid in man. Lancet 1: 616–617 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Kenny, M.T. and Strates, Metabolism and pharmacokinetics of the antibiotic rifampin. Drug Metabolism Reviews 12: 159–218 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Nair, K.G.S.: Epstein, I.G.: Baron, H. and Mulinos, M.G.: Absorption, distribution and excretion of cycloserine in man. Antibiotics Annual — 1955-1956: 136–140 (1956).

    Google Scholar 

  • Place, V.A.: Pyle, M.M. and Huergo, J. de la: Ethambutol in tuberculous meningitis. American Review of Respiratory Diseases 99: 783–784 (1969).

    CAS  Google Scholar 

  • Sippel, J.E.: Mikhail, I.A.: Girgis, N.I. and Youssef, N.I.: Rifampin concentration in cerebrospinal fluid of patients with tuberculous meningitis. American Review of Respiratory Diseases 109: 579–580 (1974).

    CAS  Google Scholar 

  • Yoshikawa, T.T. and Fujita, N.K.: Antituberculous drugs. Medical Clinics of North America 66: 209–218 (1982).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Louisiana State University Medical Center ]Department of Pharmacology and Experimental Therapeutics, 1901 Perdido Street, New Orleans, Louisiana, LA 70112, USA

    Mack R. Holdiness

Authors
  1. Mack R. Holdiness
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Holdiness, M.R. Cerebrospinal Fluid Pharmacokinetics of the Antituberculosis Drugs. Clin Pharmacokinet 10, 532–534 (1985). https://doi.org/10.2165/00003088-198510060-00006

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003088-198510060-00006

Keywords

Search

Navigation