Abstract
During inflammation, expression of various P450 genes is modulated differentially. Both the downregulation of some P450s and the induction of others may be the result of a complex interaction involving inflammatory cytokines, stress hormones, and metabolic perturbations. Our results suggest that NO is not an important mediator for the downregulation of CYP2C11 in rat liver.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Aryl Hydrocarbon Hydroxylases*
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Communicable Diseases / enzymology*
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Communicable Diseases / genetics
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Cytochrome P-450 Enzyme System / genetics
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Cytochrome P-450 Enzyme System / metabolism*
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Down-Regulation / drug effects
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Glucocorticoids / pharmacology
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Humans
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Inflammation / enzymology*
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Inflammation / genetics
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Nitric Oxide / physiology*
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Pharmaceutical Preparations / metabolism*
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Pharmacokinetics
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Steroid 16-alpha-Hydroxylase*
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Steroid Hydroxylases / genetics
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Stress, Physiological / enzymology
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Stress, Physiological / genetics*
Substances
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Glucocorticoids
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Pharmaceutical Preparations
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Nitric Oxide
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Cytochrome P-450 Enzyme System
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Steroid Hydroxylases
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Aryl Hydrocarbon Hydroxylases
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Steroid 16-alpha-Hydroxylase