Abstract
Vitamin D and retinoids are important regulators of differentiation and proliferation in a number of tissues, and have been implicated as chemopreventive agents in several different tumors. While vitamin D is known to be important for regulation of parathyroid function and proliferation, it has recently been established that parathyroid cells also are targets for retinoids. Hyperparathyroidism (HPT) is a common disorder, and evaluation of the disease has indicated high prevalence of subclinical disease, as well as clear benefits of offering treatment for the disease. This review summarizes the data so far gathered concerning parathyroid cells, vitamin D and retinoids, with clear implication on prospects of possible medical treatment of hyperparathyroidism.
MeSH terms
-
Animals
-
Calcium-Binding Proteins / genetics
-
Calcium-Binding Proteins / metabolism
-
Cell Differentiation
-
Cell Division
-
Humans
-
Hyperthyroidism / drug therapy*
-
Hyperthyroidism / physiopathology*
-
Parathyroid Glands / physiology*
-
Parathyroid Hormone / genetics
-
Parathyroid Hormone / metabolism
-
Polymorphism, Genetic
-
Receptors, Calcitriol / genetics
-
Receptors, Retinoic Acid / genetics
-
Receptors, Retinoic Acid / metabolism
-
Retinoid X Receptors
-
Retinoids / metabolism*
-
Retinol-Binding Proteins / metabolism
-
Transcription Factors / metabolism
-
Transcription, Genetic
-
Vitamin A / metabolism
-
Vitamin D / pharmacology
-
Vitamin D / physiology*
Substances
-
Calcium-Binding Proteins
-
Parathyroid Hormone
-
Receptors, Calcitriol
-
Receptors, Retinoic Acid
-
Retinoid X Receptors
-
Retinoids
-
Retinol-Binding Proteins
-
Transcription Factors
-
Vitamin A
-
Vitamin D