Abstract
One way that bacteria resist antimicrobial agents involves 'drug sensors', proteins that bind a range of structurally unrelated antimicrobial drugs and induce expression of multidrug resistance pumps. The basis for drug recognition is now becoming clear from the recently determined crystal structure of a drug sensor.
MeSH terms
-
Anti-Bacterial Agents
-
Bacterial Proteins / metabolism
-
Binding Sites
-
Carrier Proteins / metabolism
-
Cations
-
Drug Resistance, Microbial
-
Drug Resistance, Multiple / physiology*
-
Membrane Transport Proteins*
-
Trans-Activators / chemistry
-
Trans-Activators / metabolism*
Substances
-
Anti-Bacterial Agents
-
Bacterial Proteins
-
BmrR protein, bacteria
-
Carrier Proteins
-
Cations
-
Membrane Transport Proteins
-
Trans-Activators
-
Bmr protein, Bacillus subtilis