Abstract
The use of conventional nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with upper gastrointestinal bleeding and perforation (UGIB), acute liver injury, acute renal injury, heart failure, and adverse reproductive outcomes. This article summarizes the effects of various factors, such as NSAID dose, duration of treatment, patient age, and ulcer history, on the incidences of these adverse side effects. We used the UK General Practice Research Database to study further the principal safety concern related to NSAIDs, namely, UGIB.
MeSH terms
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Acute Disease
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Adult
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Aged
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Chemical and Drug Induced Liver Injury*
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Databases, Factual
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Family Practice
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Female
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Gastrointestinal Hemorrhage / chemically induced*
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Gastrointestinal Hemorrhage / epidemiology*
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Heart Failure / chemically induced*
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Heart Failure / epidemiology*
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Humans
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Incidence
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Kidney Diseases / chemically induced*
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Kidney Diseases / epidemiology*
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Liver Diseases / epidemiology*
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Male
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Middle Aged
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Pharmacoepidemiology
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Pregnancy
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Reproduction / drug effects*
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Risk Factors
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Safety*
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United Kingdom / epidemiology
Substances
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Anti-Inflammatory Agents, Non-Steroidal