Abstract
We examined the cytotoxicity of troglitazone toward cultured rat hepatocytes. The drug concentration- and time-dependently decreased cell viability and increased lactate dehydrogenase leakage from the cells. Troglitazone-induced cell death was characterized by "DNA ladders", condensation of nuclei, and a positive reaction to in situ nick-end labeling. The results indicate that troglitazone can cause apoptotic cell death in cultured rat hepatocytes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Nucleus / drug effects
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Cell Nucleus / pathology
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Cell Survival / drug effects
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Cells, Cultured
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Chromans / toxicity*
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DNA Fragmentation / drug effects
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Dose-Response Relationship, Drug
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Hepatocytes / drug effects*
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Hypoglycemic Agents / toxicity*
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In Situ Nick-End Labeling
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Male
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Rats
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Rats, Wistar
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Thiazoles / toxicity*
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Thiazolidinediones*
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Troglitazone
Substances
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Chromans
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Hypoglycemic Agents
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Thiazoles
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Thiazolidinediones
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Troglitazone