Allosteric behavior in cytochrome p450-dependent in vitro drug-drug interactions: a prospective based on conformational dynamics

Chem Res Toxicol. 2001 Apr;14(4):338-47. doi: 10.1021/tx0002132.

Authors

W M Atkins¹, R W Wang, A Y Lu

Affiliation

¹ Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA. winky@u.washington.edu

PMID: 11304120
DOI: 10.1021/tx0002132

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Allosteric Regulation
Cytochrome P-450 Enzyme System / chemistry
Cytochrome P-450 Enzyme System / metabolism*
Drug Interactions*
In Vitro Techniques
Kinetics
Pharmaceutical Preparations / chemistry
Protein Conformation

Substances

Pharmaceutical Preparations
Cytochrome P-450 Enzyme System