Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site

Adv Exp Med Biol. 2001:500:347-50.
No abstract available

MeSH terms

  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / metabolism*
  • Cytochromes b5 / metabolism
  • Heme / metabolism*
  • Humans
  • Microsomes, Liver / metabolism
  • Mixed Function Oxygenases / metabolism*
  • Reactive Oxygen Species / metabolism*
  • Triazolam / metabolism*

Substances

  • Reactive Oxygen Species
  • Triazolam
  • Heme
  • Cytochromes b5
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • CYP3A protein, human
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human