Abstract
Multidrug resistance (MDR) of neoplastic cells, i.e. resistance towards large groups of unrelated drugs, represents the phenomenon that dramatically depresses the effectiveness of cancer chemotherapy. Membrane transport of ATPases from ABC superfamily plays an important role in MDR. In the present paper we are aiming to compare two members of this family: P-glycoprotein (PGP products of mdr genes) and multidrug resistance-associated protein (MRP, products of mrp genes) and their impact for MDR of neoplastic cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
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Animals
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Antineoplastic Agents / pharmacology*
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Biological Transport
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Cell Membrane / metabolism
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Drug Resistance, Neoplasm*
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Models, Biological
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Multidrug Resistance-Associated Proteins / metabolism
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Neoplasms / drug therapy
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Neoplasms / metabolism
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Antineoplastic Agents
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Multidrug Resistance-Associated Proteins
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multidrug resistance-associated protein 1