Rapid determination of pharmacokinetic properties of new chemical entities: in vivo approaches

Kathleen A Cox; Ronald E White; Walter A Korfmacher

doi:10.2174/1386207023330534

Rapid determination of pharmacokinetic properties of new chemical entities: in vivo approaches

Comb Chem High Throughput Screen. 2002 Feb;5(1):29-37. doi: 10.2174/1386207023330534.

Authors

Kathleen A Cox¹, Ronald E White, Walter A Korfmacher

Affiliation

¹ Department of Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.

PMID: 11860337
DOI: 10.2174/1386207023330534

Abstract

There is a continuing need for increased throughput in the evaluation of new chemical entities in terms of their pharmacokinetic (PK) parameters as part of new drug discovery. This review summarizes various approaches that have been used to increase throughput in this area. The article divides the approaches into two areas: assay enhancement and sample reduction.

Publication types

Review

MeSH terms

Animals
Chromatography, High Pressure Liquid / instrumentation
Chromatography, High Pressure Liquid / methods
Gas Chromatography-Mass Spectrometry / instrumentation
Gas Chromatography-Mass Spectrometry / methods
Pharmaceutical Preparations / administration & dosage*
Pharmacokinetics*
Spectrometry, Mass, Electrospray Ionization / instrumentation
Spectrometry, Mass, Electrospray Ionization / methods

Substances

Pharmaceutical Preparations