Abstract
There is a continuing need for increased throughput in the evaluation of new chemical entities in terms of their pharmacokinetic (PK) parameters as part of new drug discovery. This review summarizes various approaches that have been used to increase throughput in this area. The article divides the approaches into two areas: assay enhancement and sample reduction.
MeSH terms
-
Animals
-
Chromatography, High Pressure Liquid / instrumentation
-
Chromatography, High Pressure Liquid / methods
-
Gas Chromatography-Mass Spectrometry / instrumentation
-
Gas Chromatography-Mass Spectrometry / methods
-
Pharmaceutical Preparations / administration & dosage*
-
Pharmacokinetics*
-
Spectrometry, Mass, Electrospray Ionization / instrumentation
-
Spectrometry, Mass, Electrospray Ionization / methods
Substances
-
Pharmaceutical Preparations