Species and strain differences in target organ alkylation and toxicity by 4-ipomeanol. Predictive value of covalent binding in studies of target organ toxicities by reactive metabolites

Biochem Pharmacol. 1979 Dec 1;28(23):3367-72. doi: 10.1016/0006-2952(79)90074-1.
No abstract available

MeSH terms

  • Alkylation
  • Animals
  • Cricetinae
  • Dose-Response Relationship, Drug
  • Furans / metabolism
  • Furans / toxicity
  • Guinea Pigs
  • Lethal Dose 50
  • Male
  • Mesocricetus
  • Mice
  • Mice, Inbred Strains
  • NADPH-Ferrihemoprotein Reductase / metabolism
  • Organ Specificity
  • Rabbits
  • Rats
  • Species Specificity
  • Terpenes / metabolism*
  • Terpenes / toxicity
  • Toxins, Biological / metabolism*
  • Toxins, Biological / toxicity

Substances

  • Furans
  • Terpenes
  • Toxins, Biological
  • NADPH-Ferrihemoprotein Reductase
  • 4-ipomeanol