Abstract
Cyclooxygenase inhibition studies with novel indomethacin alkanolamides demonstrate the potential for dramatic differences in inhibitor properties conferred by subtle structural modifications. The transformation of non-selective alpha-(S)-substituted indomethacin ethanolamides to potent, COX-2 selective inhibitors by simple stereocenter inversion highlights this property.
MeSH terms
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Cyclooxygenase 2
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors / metabolism
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Cyclooxygenase Inhibitors / pharmacology*
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Isoenzymes / drug effects*
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Isoenzymes / metabolism
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Prostaglandin-Endoperoxide Synthases / drug effects*
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Prostaglandin-Endoperoxide Synthases / metabolism
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Stereoisomerism
Substances
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Isoenzymes
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases