Myoclonic involuntary movement associated with chronic manganese poisoning

J Neurol Sci. 2002 Jul 15;199(1-2):93-6. doi: 10.1016/s0022-510x(02)00111-9.

Abstract

We report a 17-year-old man showing myoclonic involuntary movement (IVM) associated with chronic manganese (Mn) poisoning. The patient, a welder, showed myoclonic IVM mainly in the right upper and lower extremities, elevated levels of Mn in the blood and hair and high-intensity signals in the globus pallidus on T1-weighted MR images. Chelation therapy resulted in improvement of the myoclonic IVM and MRI abnormalities. This is the first report of Mn poisoning characterized by myoclonic IVM without parkinsonism.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Brain / pathology
  • Chelating Agents / therapeutic use
  • Electroencephalography
  • Electromyography
  • Globus Pallidus / pathology
  • Hair / chemistry
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Manganese / analysis
  • Manganese / blood
  • Manganese Poisoning / complications*
  • Manganese Poisoning / diagnosis*
  • Manganese Poisoning / drug therapy
  • Manganese Poisoning / pathology
  • Myoclonus / chemically induced*
  • Myoclonus / diagnosis*
  • Myoclonus / drug therapy
  • Occupational Exposure

Substances

  • Chelating Agents
  • Manganese