Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein

Clin Pharmacol Ther. 2002 Nov;72(5):474-89. doi: 10.1067/mcp.2002.128388.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology*
  • Animals
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / physiology*
  • Erythromycin / pharmacokinetics
  • Humans
  • Metabolic Clearance Rate
  • Midazolam / pharmacokinetics
  • Sex Characteristics

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Erythromycin
  • Cytochrome P-450 Enzyme System
  • CYP3A protein, human
  • Cytochrome P-450 CYP3A
  • Midazolam