Proteolysis, proteasomes and antigen presentation

A L Goldberg; K L Rock

doi:10.1038/357375a0

Proteolysis, proteasomes and antigen presentation

Nature. 1992 Jun 4;357(6377):375-9. doi: 10.1038/357375a0.

Authors

A L Goldberg¹, K L Rock

Collaborator

A L Goldberg²

Affiliations

¹ Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, Massachusetts.
² Harvard Med Sch, Boston, MA

PMID: 1317508
DOI: 10.1038/357375a0

Abstract

Proteins presented to the immune system must first be cleaved to small peptides by intracellular proteinases. Proteasomes are proteolytic complexes that degrade cytosolic and nuclear proteins. These particles have been implicated in ATP-ubiquitin-dependent proteolysis and in the processing of intracellular antigens for cytolytic immune responses.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Adenosine Triphosphate / metabolism
Adenosine Triphosphate / pharmacology
Antigen-Presenting Cells / immunology*
Antigens / immunology
Antigens / metabolism*
Endopeptidases / metabolism*
Proteins / metabolism*
T-Lymphocytes / immunology
Ubiquitins / pharmacology

Substances

Antigens
Proteins
Ubiquitins
Adenosine Triphosphate
Endopeptidases