Microbial transformation of immunosuppressive compounds. II. Specific desmethylation of 13-methoxy group of FK 506 and FR 900520 by an unidentified Actinomycete ATCC 53828 [corrected]

J Antibiot (Tokyo). 1992 Apr;45(4):577-80. doi: 10.7164/antibiotics.45.577.
No abstract available

MeSH terms

  • Actinomyces / chemistry
  • Actinomyces / metabolism
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / metabolism*
  • Anti-Bacterial Agents / pharmacology
  • Immunosuppressive Agents / chemistry
  • Immunosuppressive Agents / metabolism*
  • Immunosuppressive Agents / pharmacology
  • Lymphocyte Activation / drug effects
  • Magnetic Resonance Spectroscopy
  • Methylation
  • Piperidines / chemistry
  • Piperidines / isolation & purification
  • Piperidines / metabolism*
  • Piperidines / pharmacology
  • Spectrometry, Mass, Fast Atom Bombardment
  • T-Lymphocytes / drug effects
  • Tacrolimus / analogs & derivatives*
  • Tacrolimus / chemistry
  • Tacrolimus / isolation & purification
  • Tacrolimus / metabolism*
  • Tacrolimus / pharmacology

Substances

  • Anti-Bacterial Agents
  • Immunosuppressive Agents
  • Piperidines
  • L 685487
  • L 683519
  • immunomycin
  • Tacrolimus