Epoxomicin, a new antitumor agent of microbial origin

J Antibiot (Tokyo). 1992 Nov;45(11):1746-52. doi: 10.7164/antibiotics.45.1746.

Abstract

An actinomycete strain No. Q996-17 produced a novel compound, epoxomicin, which exhibited in vivo antitumor activity against B16 melanoma. Structural studies indicated that it is a new member of the epoxy-beta-aminoketone group, and is closely related to eponemycin.

Publication types

  • Comparative Study

MeSH terms

  • Actinomycetales / metabolism*
  • Amides / therapeutic use
  • Anti-Bacterial Agents / biosynthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / therapeutic use
  • Antibiotics, Antineoplastic* / biosynthesis
  • Antibiotics, Antineoplastic* / chemistry
  • Antibiotics, Antineoplastic* / therapeutic use
  • Chemical Phenomena
  • Chemistry, Physical
  • Fermentation
  • Magnetic Resonance Spectroscopy
  • Melanoma, Experimental / drug therapy
  • Molecular Structure
  • Oligopeptides
  • Serine / analogs & derivatives
  • Serine / therapeutic use
  • Spectrophotometry

Substances

  • Amides
  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Oligopeptides
  • eponemycin
  • Serine
  • epoxomicin