Abstract
An actinomycete strain No. Q996-17 produced a novel compound, epoxomicin, which exhibited in vivo antitumor activity against B16 melanoma. Structural studies indicated that it is a new member of the epoxy-beta-aminoketone group, and is closely related to eponemycin.
MeSH terms
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Actinomycetales / metabolism*
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Amides / therapeutic use
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Anti-Bacterial Agents / biosynthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / therapeutic use
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Antibiotics, Antineoplastic* / biosynthesis
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Antibiotics, Antineoplastic* / chemistry
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Antibiotics, Antineoplastic* / therapeutic use
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Chemical Phenomena
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Chemistry, Physical
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Fermentation
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Magnetic Resonance Spectroscopy
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Melanoma, Experimental / drug therapy
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Molecular Structure
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Oligopeptides
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Serine / analogs & derivatives
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Serine / therapeutic use
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Spectrophotometry
Substances
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Amides
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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Oligopeptides
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eponemycin
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Serine
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epoxomicin