Redox cycling of beta-lapachone and structural analogues in microsomal and cytosol liver preparations

Methods Enzymol. 2004:378:67-87. doi: 10.1016/S0076-6879(04)78004-0.

Authors

Silvia Fernández Villamil¹, Andrés O M Stoppani, Marta Dubin

Affiliation

¹ Bioenergetics Research Centre, National Research Council, School of Medicine, University of Buenos Aires, Argentine.

PMID: 15038958
DOI: 10.1016/S0076-6879(04)78004-0

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents / therapeutic use
Cytosol / enzymology
Cytosol / metabolism*
Electron Spin Resonance Spectroscopy
Humans
Liver Extracts / metabolism*
Microsomes / enzymology
Microsomes / metabolism*
Molecular Structure
NADP / metabolism
NADPH-Ferrihemoprotein Reductase / metabolism
Naphthoquinones / chemistry
Naphthoquinones / metabolism*
Naphthoquinones / pharmacology
Neoplasms / drug therapy
Neoplasms / metabolism
Oxidation-Reduction
Reactive Oxygen Species / metabolism*
Reactive Oxygen Species / toxicity

Substances

Antineoplastic Agents
Liver Extracts
Naphthoquinones
Reactive Oxygen Species
NADP
beta-lapachone
1,2-naphthoquinone
NADPH-Ferrihemoprotein Reductase